Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons
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چکیده
منابع مشابه
MCH neurons: vigilant workers in the night.
1783 Critical Topics Forum—Jego and Adamantidis Since the discovery of the MCH peptide1 and the identification of its receptor(s),2 experimental and clinical studies have demonstrated a role for the MCH peptide in many hypothalamic functions, from energy homeostasis and stress response to learning and memory, stress/anxiety, LTP, and sleep.3 This heterogeneity of functions is consistent with th...
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Melanin-concentrating hormone (MCH)-expressing neurons have been ascribed many roles based on studies of MCH-deficient mice. However, MCH neurons express other neurotransmitters, including GABA, nesfatin, and cocaine-amphetamine-regulated transcript. The importance of these other signaling molecules made by MCH neurons remains incompletely characterized. To determine the roles of MCH neurons in...
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15 صفحه اولCharacterization of MCH-mediated obesity in mice.
Melanin-concentrating hormone (MCH) is a cyclic orexigenic peptide expressed in the lateral hypothalamus. Recently, we demonstrated that chronic intracerebroventricular infusion of MCH induced obesity accompanied by sustained hyperphagia in mice. Here, we analyzed the mechanism of MCH-induced obesity by comparing animals fed ad libitum with pair-fed and control animals. Chronic infusion of MCH ...
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Neurons that synthesize melanin-concentrating hormone (MCH) colocalize GABA, regulate energy homeostasis, modulate water intake, and influence anxiety, stress, and social interaction. Similarly, vasopressin and oxytocin can influence the same behaviors and states, suggesting that these neuropeptides may exert part of their effect by modulating MCH neurons. Using whole cell recording in MCH-gree...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2018
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2018.05.001